The route starts in SW St. Louis City, at the intersection of Gravois Ave., Hampton Ave., and Germania St. Take Germania St. south along the River Des Peres for 2 miles. Continue through the intersection with Alabama St. onto Marceau St. In 0.4 miles, turn right onto South Broadway. In 0.4 miles, after crossing over the River Des Peres, turn right onto River City Casino Blvd. In 0.5 miles, continue straight onto River City Blvd. In 0.6 miles, continue straight onto River Des Peres Blvd. Continue for 3.2 miles to the end of River Des Peres Blvd at the intersection with Lansdowne Blvd.
The route follows the River Des Peres, which is a channelized river. There are residential neighborhoods on both sides of the river, with a "greenway" and walking/biking trails paralleling the road on the south/west side of the river.
The route is all St. Louis City maintained streets. The beginning of the route is primarily asphalt, with some rough areas. Once you cross over the river on Broadway, the route is mostly old "chip and seal" surface, which is very rough, and can have some noticeable pitting and potholes along the lane seams and outside edges.
The route goes past the River City Casino at the southern end of the route. The route crosses over Chippewa St./Watson Rd., which is one of the major alignments for Route 66 through St. Louis. Just east of the route on Chippewa is Ted Drewes Frozen Custard, a world famous Route 66 attraction. There are a number of restaurants and shops just off of the route on all of the major cross streets.