Take 220 north out of Greensboro. After crossing the Virginia state line take US58 North just before Martinsville.After approximately 40 miles, take the Blue Ridge Pkwy east to Mabry Mill. Great little breakfast place there by the old mill. Get back on the Pkwy and head west until you get to US52. head back south on 52 all the way to Winston-Salem.
US58 and the Blue Ridge Pkwy is absolutely beautiful. Mabry Mill is one of the oldest water mills still in operation in the beautiful Virginia countryside.
There are some sweeping turns, and some sharp turns for the first half of the trip. 52 south is more traditional with a few sweeps. All of the roads are fairly new pavement and a very comfortable ride.
Several small communities along the way until you hit the Pkwy. Then it's all about the lookout stops with very few amenities until you hit 52 south. The breakfast at the Mabry Mill Restaurant is Excellent!
Motorcycle Road Additional info
It's a nice little day trip to start out on at around 7AM. Stop for Breakfast at Mabry Mill and it puts you on the Pkwy around 10:30-11:00AM, and depending on how many scenic stops you make you'll hit the US52 exit at around 2PM. It's the warmest and best part of the day to be on the Pkwy.