River Kings Row - By mchance

This is definitely a "cruising" road. While there's lots of smaller towns, once you clear the St. Louis exurbs and turn south at the US 61/US 67 split just south of Festus/Crystal City, the road opens up between the towns with speed limits of 55-60 MPH and sweeping turns and rolling hills. And, while there may not be a lot of tourist attractions directly on the highway, both Ste. Genevieve and Cape Girardeau have multiple historic sites, plus you can take a quick detour just before Perryville on Hwy 51 and cross the Mississippi River into Chester, the home of Popeye.