I got on Route 800 just south from I-70 (which is near the town of Barnesville, OH). There is just a gas station at off ramp when you get off of I-70 but Barnesville is just down the road and has more to offer. The twisty, fun part of the road doesn't start till south of Barnesville. i took a couple of side trips off 800 down 145/556 and circled back onto 800 from 536/78. When you get past Woodsfield you will be traveling through the Wayne National forest.
Very scenic beautiful views. The part i drove passed through the southern ohio rolling hills with some farms and wooded areas mixed in. i live in farm country and usually not real receptive to country views as i see it everyday but 800 and had me saying "isn't that pretty."
Great quality pavement and maintenance on this road. I wouldn't hesitate to ride the stiffest roughest riding bike/car. Lots and Lots of high speed sweepers and smooth curves. not a lot of passing opportunities so if your stuck behind someone, use the chance to pass when its there, don't hesitate or you'll be stuck for awhile.
Not a lot of amenities or stop as only small towns dot along the road. No real chain restaurants, just mom and pop stops and gas stations. Nice chance to get away from the cookie cutter towns along the interstate though.