There are plenty of places to obtain gas or food at the beginning and end of the route and a couple places in between. But they are scattered - so start with full gas tank and stomach.
I recommend taking a bathroom break at Sneedville as there are no other stops until you get to Cumberland Gap area.
Special Notes:
I-40 and I-81 save time for the best part of the ride. The fun starts at Hwy 70 and continues on 33, 63. Hwy 70, 33, and 63 are all nice MC Roads. Hwy 63 is steep, twisty, switchback, for 3 milse the rest of the route goes thru a beautiful valley and then a nice cruising curvy road from intersection 345/63. Also, an old country store (Martin Grocery)on 63 at a "T" Intersection just after Sneedville (drinks, cold sandwiches, friendly lady runs it - no bathroom). See Picture.
Cumberland Gap, TN is well worth a stop to tour the town, even hike the Gap Trail if you desire or a short part to an old smelter. Then thru the tunnel into KY and the Cumberland Gap Visitor center (movies and a beautiful switchback road to the Overlook where you see TN. VA, KY). See pictures.
A couple of highlights on the return home are a mountain road, Blankenship Rd (see picture)and Joppa Mountain Road with curves and switchbacks.
Alternate Route Return - stay on 25E to I-81 to I-40 or check TN Map .